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CAS No.: 163680-77-1

甲磺酸帕珠沙星 Catalog No. CSN16101

Synonyms: T-3762;Pazufloxacin methanesulfonate;Pazufloxacin mesilate

Pazufloxacin Mesylate is a fluoroquinolone antibiotic working by inhibiting both DNA gyrase and topoisomerase IV.

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生物活性

描述Pazufloxacin Mesylate (T-3761), a new quinolone derivative, showed broad and potent antibacterial activity. Its MICs for 90% of the strains tested were 0.20 to 100 micrograms/ml against gram-positive bacteria, including members of the genera Staphylococcus, Streptococcus, and Enterococcus; 0.025 to 3.13 micrograms/ml against gram-negative bacteria, including members of the family Enterobacteriaceae and the genus Haemophilus; 0.05 to 50 micrograms/ml against glucose nonfermenters, including members of the genera Pseudomonas, Xanthomonas, Acinetobacter, Alcaligenes, and Moraxella; 0.025 micrograms/ml against Legionella spp.; and 6.25 to 25 micrograms/ml against anaerobes, including Bacteroides fragilis, Clostridium difficile, and Peptostreptococcus spp^[3]. The 50% inhibitory concentrations of T-3761 for DNA gyrases isolated from E. coli and P. aeruginosa were 0.88 and 1.9 micrograms/ml, respectively^[4]. All regimens of pazufloxacin administration were well tolerated. Pazufloxacin exhibits lack of dose proportionality over the dose range of 300 - 1,000 mg^[5]. Pazufloxacin methanesulphonate at the dose of 300 mg and 500 mg have similar efficacy in treating acute bacterial infections. The dosage regimen of 300 mg Q12h intravenous infusion is recommended^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03675841	Chronic Suppurative Otitis Med... more >>ia Collapse <<	Phase 1	Recruiting	June 28, 2019	China, Jiangsu ... more >> Jiangsu Province People's Hospital Recruiting Nanjing, Jiangsu, China, 210029 Contact: lei chen, PHD 13776620807 jspent@126.com Contact: fen shao, PHD 13851691161 shaofengnj@163.com Collapse <<
NCT02592096	Otitis Media	Phase 1	Unknown	February 2016	China ... more >> Qingdao Municipal Hospital Recruiting Qingdao, China, 266011 Contact: Weiguo XUE, MD Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4131 mL
- 12.0653 mL
- 24.1307 mL
- 5 mM
- 0.4826 mL
- 2.4131 mL
- 4.8261 mL
- 10 mM
- 0.2413 mL
- 1.2065 mL
- 2.4131 mL

技术信息

CAS号

163680-77-1

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H19FN2O7S

运输

蓝冰

分子量

414.41

别名

T-3762;Pazufloxacin methanesulfonate;Pazufloxacin mesilate;Pazufloxacin (mesylate);Pazufloxacin Mesylate;Pazucross;Pasil;帕珠沙星甲磺酸盐;甲磺酸帕珠沙星

溶解度

DMSO	50.0 mg/mL (120.7 mM)

动物实验配方

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